The Center for iPS Cell Research and Application (CiRA) was established to develop iPS cell-based technologies for the benefit of patients afflicted with intractable diseases, and to function as a world-leading iPS cell research institute. Under the direction of Prof. Shinya Yamanaka, Nobel Laureate in Physiology or Medicine 2012, approximately 30 research groups work to achieve those goals. Laboratories are organized into five departments focusing on reprogramming, cell growth and differentiation, clinical applications, fundamental cell technology, and ethics. Our research building is equipped with core facilities for animal research and cell processing, and enables seamless movement from basic labs to preclinical and clinical teams. Over the decade, CiRA will work on establishing basic iPS cell technologies, acquiring patents, building an iPS cell bank, conducting preclinical and clinical research, and supporting drug screening and development.